Evaluation of the results of several genotoxicity tests in carvacrol and thymol

Carvacrol (CAS# 499-75-2) and thymol (89-83-8) are fragrance ingredients that have been studied in bacterial and mammalian geno-toxicity assays in vitro and in an in vivo chromosome aberration test.

Both assays yielded negative results, supporting the hypothesis that the previous positive genotoxic outcomes were the result of high cytotoxic activity in the test system and that carvacrol and thymol are likely not genotoxic agents.

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