A Special Issue: Dermal Sensitization Quantitative Risk Assessment for Fragrance Ingredients

This Special Issue on the Quantitative Risk Assessment (QRA) for Fragrance Ingredients is published in Regulatory Toxicology and Pharmacology, (Vol. 52, No. 1, October 2008), the official peer-reviewed scientific journal of the International Society of Regulatory Toxicology and Pharmacology.

The QRA is now the basis for IFRA Standards on ingredients exhibiting a potential for dermal sensitization and has led to the Standards having individual restrictions for 11 product categories. The categories were achieved by grouping consumer product types according to key parameters identified within the QRA approach. These parameters are Sensitization Assessment Factors (SAFs) and consumer product exposure, which when combined, lead to acceptable use levels of a fragrance ingredient. This is the most current and comprehensive publication on the QRA.

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