Assessment Tools


RIFM developed a number of Assessment Tools and Methodologies to improve or aid the safety evaluation of fragrance materials. Almost all are available to RIFM Database subscribers in the Tools and Models section of the Database. The TDSE and SAM tools are available to all RIFM Members from this web site(login to the RIFM Member Area required).

The Creme/RIFM Aggregate Exposure Model - A standard approach that can be widely used by the fragrance industry for total systemic exposure.

Toxicology Data Search Engine (TDSE) Web Application - By inputting one or more CAS numbers, the TDSE simultaneously searches 8 commonly used toxicological databases and collates the results.

Skin Absorption Model (SAM) - An in silico skin absorption model for fragrance ingredients. Read more about SAM in Food and Chemical Toxicology 74 (2014) 164-176.

From the RIFM Database (subscription needed)
​The 2-Box Air Dispersion Model - Uses room within a room technology to calculate peak air concentrations from 3 product categories, Aerosol Air Fresheners, Candles/Incense and Plug-In Air Fresheners/Reed Diffusers. This model will establish inhalation Toxicological Threshold of Concern (TTC).

The Multiple Path Particle Dosimetry (MPPD) Inhalation Exposure Model - Predicts deposition patterns in the airway and determines the deposited dose. Based on knowledge of the cell types in the regions of greatest deposition, the computational model will allow for the prediction of potential physiological effects.

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