The RIFM Human Health Science Program
The RIFM Environmental Program
The RIFM Database
Understanding the potential for exposure to a material is essential for completing a safety evaluation. To improve how RIFM carries out Safety Evaluations on fragrance materials, RIFM, in collaboration with member companies and an external resource, Creme Global, developed an aggregate exposure model and database customized to the scientific requirements and business needs of RIFM members. The model provides improved calculation of total systemic consumer exposure to fragrance materials. The refined systemic exposure data becomes part of RIFM's Fragrance Safety Evaluations. The model is only available to RIFM Members.
Scientific and regulatory staff of RIFM Member companies involved in the preparation of fragrances for consumer products can take advantage of this probabilistic aggregate exposure model which takes into account multiple routes of exposure. Benefits of using the model include:
Creme Global is a well-established partner to Industry for modeling exposure to cosmetics and foods, whose methodology is accepted by regulators. Creme's software for food safety analysis is used by the European Food Safety Authority (EFSA), the Food Safety Authority of Ireland (FSAI), the United States Department of Agriculture (USDA) and the US Food and Drug Administration (FDA).
View a presentation on the Creme RIFM Aggregate Exposure Model.
RIFM Members can view a demo presentation of the Creme-RIFM Aggregate Exposure Model in the Event Area of the Member Section of this site (login required). See RIFM's 47th Annual Meeting Event page.
To learn more about this special project, you can visit Creme's web site, www.cremeglobal.com/products/creme-rifm.
The Creme RIFM Aggregate Exposure Model is only available to RIFM Members after they have logged in on Creme's web site.
To login for Data submission, go to http://rifmportal.cremeglobal.com/.
For a tutorial on submitting your data through the RIFM Data Portal, visit http://rifm.cremeglobal.com/manual/index.php/RIFM_Data_Portal/.
Published Studies on the Creme-RIFM Aggregate Exposure Model
Novel Database for exposure to fragrance ingredients in cosmetics and personal care products, D. Comiskey et al, Regulatory Toxicology and Pharmacology, 72 (2015)660-672. Read More
For questions about the Creme-RIFM Aggregate Exposure Model, e-mail Dr. Anne Marie Api, firstname.lastname@example.org.