The RIFM Human Health Science Program


Creme - RIFM Aggregate Exposure Model for Fragrance Materials

Understanding the potential for exposure to a material is essential for completing a safety evaluation. To improve how RIFM carries out Safety Evaluations on fragrance materials, RIFM, in collaboration with member companies and an external resource, Creme Global, developed an aggregate exposure model and database customized to the scientific requirements and business needs of RIFM members. The model provides improved calculation of total systemic consumer exposure to fragrance materials. The refined systemic exposure data becomes part of RIFM's Fragrance Safety Evaluations. The model is available to any interested company. License and access are provided by Creme Global from their website, 

The scientific and regulatory staff of RIFM Member companies involved in the preparation of fragrances for consumer products can take advantage of this probabilistic aggregate exposure model which takes into account multiple routes of exposure. Benefits of using the model include:

  • Avoiding over-estimation of exposure by previously ultra conservative and unrealistic methods.
  • Providing a solid scientific basis for IFRA limits for systemic effects.
  • Producing a realistic evaluation of a fragrance ingredient
  • Reducing clinical toxicity testing-saving time and money.
  • Satisfying regulators' request for information on aggregate exposure.

Creme Global is a well-established partner to Industry for modeling exposure to cosmetics and foods, whose methodology is accepted by regulators. Creme's software for food safety analysis is used by the European Food Safety Authority (EFSA), the Food Safety Authority of Ireland (FSAI), the United States Department of Agriculture (USDA) and the US Food and Drug Administration (FDA).

View the Presentation

View a presentation on the Creme RIFM Aggregate Exposure Model.

View a demo presentation of the Creme-RIFM Aggregate Exposure Model in the Event Area of this site. 

To learn more about this special project, you can visit Creme's web site, 

The Creme RIFM Aggregate Exposure Model is available after logging in to Creme's web site.

To login for Data submission, go to

For a tutorial on submitting your data through the RIFM Data Portal, visit

Published Studies on the Creme-RIFM Aggregate Exposure Model

Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic productsRegulatory Toxicology and Pharmacology, 72 (2015) pp. 673-682

Novel Database for exposure to fragrance ingredients in cosmetics and personal care productsRegulatory Toxicology and Pharmacology, 72 (2015) pp. 660-672. 

Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care productsRegulatory Toxicology and Pharmacology, 86, June 2017, pp. 148–156

Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model, Regulatory Toxicology and Pharmacology, 88, August 2017, pp. 144–156

For questions about the Creme-RIFM Aggregate Exposure Model, e-mail Dr. Anne Marie Api,