The RIFM Human Health Science Program


RIFM's Human Health Science program focuses on evaluating fragrance materials to insure the continued safe use of perfumed products by consumers.

RIFM accomplishes this by

  • Completing human health safety assessments of fragrance materials 
  • Publishing all data in peer-reviewed scientific journals
  • Developing innovative new safety assessment and testing techniques 

The Human Health Science Program evaluates available data for relevant toxicological endpoints for local and systemic effects, including but not limited to

  • genotoxicicty/carcinogenicity
  • reproductive and developmental toxicity
  • repeated dose toxicity
  • skin sensitization
  • respiratory toxicity
  • phototoxicity

If more data is needed, RIFM will conduct studies for the necessary endpoints. To investigate the effects of fragrance ingredients, the toxicology program includes routine human health studies as well as specifically designed applied research projects, mechanistic studies and new methodologies.

Since a safety assessment cannot be conducted without exposure data, RIFM has collaborated with Creme Global since 2010. Together, we have developed an Aggregate Exposure Model for fragrance ingredients that is based on actual use data. The model provides more realistic estimates of aggregate exposure of individuals across a population and represents a substantial advance from historical exposure calculation methods.

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