A Vision for the Future: RIFM publishes groundbreaking endpoint-specific read-across paper
RIFM’s Computational Chemistry lead scientist Holger Moustakas, PhD, working with a team of RIFM scientists and Expert Panel for Fragrance Safety members, just published “An Endpoint-Specific Framework for Read-Across Analog Selection for Human Health Effects” in the peer-reviewed journal Chemical Research in Toxicology.
Read-across is a safety assessment approach in which study data on one chemical can be used as a proxy to support the safe use of a structurally similar chemical lacking study data.
Dr. Moustakas discussed the importance and impact of the newly published paper in a recent Ask a RIFM Scientist posting. “Endpoint specificity in read-across analog selection makes read-across a more scientific process,” he explained. “In addition, it expands the potential read-across options RIFM scientists have, which allows them to ensure the safety of more fragrance ingredients while avoiding extra testing and saving animal lives.”
The read-across paper is available open-access for free download at pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.2c00286.