RIFM Database

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The RIFM Database is the most comprehensive worldwide source of toxicology data, literature, and general information on fragrance and flavor raw materials, classifying more than 7,000 materials supported by over 80,000 references and nearly 200,000 human health and environmental studies. 

RIFM reviews upward of 50 scientific journals each month, conducts literature searches, and regularly collects member company data to keep the RIFM Database as complete as possible.

In addition, RIFM has created and maintains several safety assessment tools (animal-alternative models and methodologies) that are available exclusively to RIFM members and database subscribers. They include:


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  • The Skin Absorption Model (SAM)
  • The Toxicology Data Search Engine (TDSE)
  • The 2-Box Air Dispersion Model
  • The Multiple Path Particle Dosimetry (MPPD) Inhalation Exposure Model

Explore Assessment Tools

Genotoxicity Data Visualization Tool (GDVT): A web application available through the RIFM database that has genotoxicity data for fragrance materials in a graphical format; includes a tabular summary of the data set with final outcome within each assay.

The MPPD Model: An assessment model developed to study the uptake of vapors and deposition of aerosol particulate/droplet components using a computational model of the nasal and lung airways of humans and rats.

The 2-Box Air Dispersion Model: An indoor environment air model that characterizes the dispersion of a single chemical inside 2 connected enclosed zones and determines air exposure concentrations. In particular, the near field model predicts concentrations and exposures for personal products applied in close proximity to the individual such as hairsprays, fine fragrances, and deodorants. The default airflow parameter from zone 2 to the outdoors has been updated to reflect 0.1 m³/min instead of the original value of 1.89 m³/min. This change more accurately reflects the flow of air from bathroom (zone 2) to the outdoors and is also a much more conservative estimate due to the decrease in mixing with fresh outdoor air.

The Skin Absorption Model (SAM) Calculator: Used to estimate the skin absorption percentage of a material. It is developed and tailored specific for fragrance and fragrance-like materials.

Toxicity Data Search Engine (TDSE): Automatically searches 9 major toxicology databases (i.e., RIFM Database, ECHA REACH dossier, NTP, HSDB, CPDB, EPA HPVIS, EPA robust summary, Japanese existing chemicals, and OECD ECD) to generate a combined accessible output.