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As regulatory approaches to chemical safety continue to evolve worldwide, findings on developmental and reproductive toxicity are receiving increasing attention from regulators, policymakers, advocacy groups, and the scientific community. At the same time, questions often arise about how results observed in laboratory studies relate to real-world human exposure and consumer safety.

Watch a recording of this timely webinar exploring the critical distinctions between dose, exposure, hazard, and risk—concepts that form the foundation of modern toxicological evaluation and risk assessment.

This webinar examined how toxicological findings generated under controlled laboratory conditions are interpreted within the context of realistic consumer exposure scenarios and broader scientific evidence. Viewers will gain insight into how toxicologists evaluate the relevance of high-dose study findings, assess human exposure, and apply a weight-of-evidence approach to determine whether observed effects are meaningful for human health.

The session also introduces RIFM’s new Developmental and Reproductive Toxicity Data Summary, an important component of a broader initiative to organize, evaluate, and communicate complex safety data in a transparent and scientifically rigorous manner. The summary serves as a foundation for expert interpretation of developmental and reproductive toxicity information and supports a comprehensive weight-of-evidence strategy that integrates hazard identification, exposure considerations, mechanistic understanding, and scientific judgment.

Moderator
Danielle Botelho, PhD
Director of Scientific Operations
Research Institute for Fragrance Materials (RIFM)

Featured Speakers
Kaushal Joshi, PhD, DABT
Principal Scientist, Repeated Dose and Reproductive Toxicology
RIFM

Aldert H. Piersma, PhD
Emeritus Professor, Reproductive Toxicology
Institute for Risk Assessment Sciences (IRAS), Utrecht University, Netherlands
Member, Expert Panel for Fragrance Safety

Yax Thakkar, PhD
Manager, Scientific Innovation & Discovery
RIFM

Topics Include:
• Understanding the differences between hazard and risk
• Why dose and exposure matter when evaluating toxicological findings
• Assessing developmental and reproductive toxicity data in a human health context
• The role of exposure assessment in fragrance safety evaluation
• RIFM’s new Developmental and Reproductive Toxicity Data Summary
• Weight-of-evidence approaches for interpreting complex toxicology datasets

Watch a recording of this webinar