Established in 1966, The Research Institute for Fragrance Materials (RIFM), a bedrock for fragrance safety, has been publishing safety assessments on thousands of fragrance materials and conducting animal-free research for over a decade. Fragrance safety is built on a well-established scientific framework that has developed over decades of research. One challenge, however, continues to arise in both technical and broader discussions: How should toxicological findings be interpreted in the context of human health and real-life fragrance use?